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Nulabel Technologies
Associate Director / Director, Medicinal Chemistry
Location: Kronos Bio
  Cambridge, MA
Job Code: DMC00418
Contact: John Rynak to apply (

Role Description:
Kronos Bio seeks an experienced, highly motivated medicinal chemist to join its research team located in Cambridge, MA. The ideal candidate is a medicinal chemist with a strong background in synthetic organic chemistry and cancer biology, driven to succeed within a hypothesis-driven, team-oriented, and multi-disciplinary biotech environment. The individual will be expected to contribute to all stages of drug discovery programs, advancing small molecules from hit identification to IND.
Principal Duties and Responsibilities:
  • Lead medicinal chemistry efforts towards recalcitrant oncology targets to clear decision points.
  • Supervise and direct the efforts of all chemistry staff, acting as a resource and mentor to team members—providing guidance, instruction, and coaching.
  • Prioritize medicinal chemistry activities, managing both internal and external chemistry resources to achieve company goals while ensuring adherence to timelines and budgets.
  • Work closely with the company’s biology team, external consultants, and senior management to develop and recommend chemistry resourcing plans and budgets to achieve Kronos Bio’s strategic goals.
  • Plan, execute, critically interpret, and optimize structure activity relationship (SAR) campaigns incorporating physicochemical properties and pharmacological function readouts.
  • Manage contract research organization (CRO) partner interactions and alignment of resources consistent with company priorities and objectives to build a strong portfolio of drug candidates.
  • Lead the design, planning and execution of multi-step syntheses of high-quality small molecules for biological screening.
  • Perform complex chemical syntheses as needed in support of project goals.
  • Possess a clear and effective communication style to disseminate project data and medicinal chemistry approach to both internal colleagues, external collaborators and Kronos Bio’s Board of Directors.
  • Build and maintain productive relationships with partners in structural biology, computational chemistry, biochemistry, pharmacology, DMPK, toxicology, and early development.
  • Lead the preparation of patent documents, peer-reviewed scientific publications and regulatory documents as appropriate.
  • Build a dynamic scientific and professional culture focused on productivity and innovation that reflects Kronos Bio’s values.
  • Maintain high standards of laboratory safety, complying with all Kronos Bio safety requirements.
Job Qualifications:
  • Ph.D. in Organic Chemistry or related field with 8+ years of industry experience working in a pharmaceutical and/or biotechnology setting as a medicinal chemist.
  • Demonstrated leadership in medicinal chemistry and drug discovery as evidenced by a strong record of scientific accomplishment and cross-functional collaboration.
  • Outstanding synthetic chemistry background and a demonstrated track record of aptitude and problem solving in medicinal chemistry.
  • Extensive working knowledge of modern medicinal chemistry and drug discovery techniques (FBDD, SBDD, multi-attribute analysis, flexible resourcing models, alternative delivery systems, etc.).
  • Demonstrated experience delivering multiple compounds from hit to IND, preferably in the field of oncology.
  • Proven ability to manage timelines and resources to drive projects toward key decision criteria.
  • Experience building and managing chemistry teams in a high-growth, matrix organization.
  • Extensive experience interfacing with, and providing scientific guidance to, CRO partners and proven ability to work efficiently in a hybrid model.
  • Keen attention to detail and a strong sense of urgency is required, as is the desire and ability to work in a multi-disciplinary and team-focused environment.
  • Excellent written and oral communication skills.

About Kronos Bio
Kronos Bio was founded in 2017 and is dedicated to the discovery and development of new therapies for cancer.  The company utilizes a novel approach to high-throughput screening of chemical libraries in order to identify binders or inhibitors of complex protein interactions, with a focus on modulating transcription factors and other challenging targets that have historically been considered ‘undruggable.’