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PRINCIPAL SCIENTIST - Structure-Based Antibody Modeling
Position Title: Principal Scientist, Stucture-Based Antibody Modeling
City: Cambridge
Region: Massachusetts
Country: USA

About Pfizer:
A career at Pfizer offers opportunity, ownership and impact. All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the biopharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.
Role Description:
We are seeking a protein structure modeling expert to design industry-leading biotherapeutics as part of Pfizer's BioMedicine Design team in Cambridge, MA. The successful candidate will join project teams in multiple therapeutic areas to optimize protein-based therapeutic leads in early through late discovery, primarily using protein structure and molecular simulation. In addition to optimization of individual leads, the candidate may analyze data across programs to develop improved models/guidelines for ensuring optimal pharmaceutical properties for biologics. Other areas of opportunity may include engineering improved protein scaffolds and evaluating/creating improved computational workflows.

Works with project teams as a primary source of knowledge for structure-based computational analysis of protein biotherapeutic leads and provides optimized designs. Effectively communicates results and recommendations to colleagues with diverse scientific backgrounds. Evaluates/implements new or improved methods to increase throughput and/or accuracy of molecular modeling workflows. Analyzes data sets to discover relationships between protein structure and key pharmaceutical properties. Engineers improved general scaffolds for protein therapeutics.
Required skills and background:
  • PhD in biochemistry, chemistry, or a related field and 0-5 years of experience in the biopharmaceutical industry
  • Use of molecular structure analysis to engineer binding between proteins and their binding partners.
  • Expertise in one or more commonly used molecular modeling software packages.
  • Programming in a Linux environment using a scripting language such as Perl or Python.
Preferred skills and background:
  • Working knowledge of antibody structure and function is a significant advantage.
  • Working knowledge of bioinformatics tools and databases.
  • Conducting research projects in a team setting, presenting results to scientists of varying technical backgrounds.
  • Experience optimizing physical properties of proteins.
  • Linux systems administration skills and knowledge of HPC environments.
  • Experience with one or more of the following software suites: Schrodinger, Rosetta, Discovery Studio, FoldX.
  • Strong track record of publication in topics involving protein structure analysis.
Physical/Mental Requirements:
  • Sitting, standing, walking, ability to perform complex data analysis and communicate complex concepts.

EEO & Employment Eligibility:
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.