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Nulabel Technologies
Senior Scientist, NMR Spectroscopist, 4784883
Location: Groton, CT, USA
To Apply: Click here ...

At Pfizer we deliver Breakthroughs That Change Patients Lives. In the Medicine Design group we play a vital role in this mission through the discovery of Pfizer’s small molecule and synthetically-derived drugs. We are seeking creative and highly motivated individuals in synthetic organic chemistry to join our world-class Medicine Design team in Groton CT to build upon our rich history of innovation in Medicinal Chemistry and Synthetic Chemistry and deliver Pfizer’s drugs of the future.
Discovering new medicines at Pfizer takes teams with a diversity of skills, behaviors and approaches. Creativity, scientific excellence, tenacity, passion, hard work, organization, teamwork, courage, open-mindedness, curiosity – are just some of the traits successful Drug Discoverers display at Pfizer, and we are looking for ambitious Synthetic Chemists, eager to see their work lead to important new medicines and scientific breakthroughs, to join our team.
The Medicine Design group in Pfizer comprises experts in the major scientific disciplines involved in the discovery and preclinical development of small molecule drugs: molecular design, synthesis, computational chemistry, pharmacology, chemical biology, structural biology, biophysics, DMPK and analytical chemistry. We have a rich history in delivering high quality drug candidates into the clinic, establishing new drug design approaches and principles, and developing synthetic innovations that drive medicinal chemistry strategies.

Position Description:
The Discovery Sciences line in Pfizer Groton is seeking applicants for an experienced Nuclear Magnetic Resonance (NMR) Spectroscopist/Structure Elucidation Scientist. Discovery Sciences supports all areas of small molecule drug development in Oncology, Inflammation &Immunology, Internal Medicine, and Rare Diseases. This position is in the department of Structural and Molecular Sciences (SMS), a multidisciplinary department within Discovery Sciences. The successful candidate will apply cutting edge NMR and biophysics technologies that will advance our portfolio and support chemistry synthesis and design in Research Unit projects. Our NMR Spectroscopists work with synthetic and design chemistry colleagues as well as other technology and project groups throughout Pfizer. In addition to extensive research NMR capabilities, this group also supports an open access NMR facility. The Discovery NMR lab is equipped with ten NMR spectrometers (400-600 MHz) using a variety of helium and nitrogen cryoprobe technology and reaction monitoring capabilities using flow NMR and conventional probes.

NMR Spectroscopists are expected to maintain the small molecule NMR fleet of instruments, keep abreast of current NMR technology advances and guide instrument purchases. As an NMR Research Scientist, you will:
  1. Characterize and elucidate the structure of small molecules, nucleic acids, macrocycles and peptides of pharmaceutical interest using multidimensional solution-phase NMR;
  2. Investigate and implement novel experiments and technologies – to improve the efficiency of NMR data acquisition/processing and/or perform conformational analysis of small molecules to support drug design;
  3. Present data to research colleagues;
  4. Keep an accurate and compliant electronic research notebook;
  5. and Interact with a diverse group of world-class scientists while focusing on making impactful contributions to pipeline projects.

  • The successful candidate will have a Ph.D. degree in chemistry or a M.S. degree with 4+ years of NMR experience and a strong background in small molecule NMR. The position will be heavily focused on all aspects of the NMR structure elucidation of small organic molecules.
  • Research experience in structure elucidation with a proven track record of accomplishments in the area of small molecule organic structure elucidation or natural products.
  • Comprehensive knowledge of NMR instrumentation (both hardware and software) and the ability to maintain a wide variety of instrumentation and automation (Bruker, JEOL, and Varian) is expected as well as a good working knowledge of either ACD or Mestre software.
  • Strong communication skills and a demonstrated ability to carry out independent research are required.
  • Strong interest and motivation to learn new technologies and concepts is expected.

  • Experience with mass spectrometry, molecular modeling, and a thorough knowledge of organic chemistry are beneficial.

Other Job Details:
  • Eligible for Employee Referral Bonus

Interested candidates please apply at: