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Nulabel Technologies
Principal Scientist, Medicinal Chemistry and Molecular Design, 4791847
Location: Cambridge, MA, USA
To Apply: Click here ...

At Pfizer we deliver Breakthroughs That Change Patients Lives. In the Medicine Design group we play a vital role in this mission through the discovery of Pfizer’s small molecule and synthetically-derived drugs. We are seeking leaders in Medicinal Chemistry to join our world-class Medicine Design team in Cambridge MA to build upon our rich history of innovation in Medicinal Chemistry and Molecular Design and deliver Pfizer’s drugs of the future.

Discovering new medicines at Pfizer takes teams with a diversity of skills, behaviors and approaches. Creativity, scientific excellence, tenacity, passion, hard work, organization, teamwork, courage, open-mindedness, curiosity – are just some of the traits successful Drug Discovers display at Pfizer, and we are looking for ambitious Medicinal Chemists, eager to see their work lead to important new medicines and scientific breakthroughs, to join our team.

The Medicine Design group in Pfizer comprises experts in the major scientific disciplines involved in the discovery and preclinical development of small molecule drugs: molecular design, synthesis, computational chemistry, pharmacology, chemical biology, structural biology, biophysics, DMPK and analytical chemistry. We have long been renowned not only for delivering high quality drug candidates into the clinic but also for establishing new drug design approaches and principles, such as the “Rule of 5” and property-based drug design, that have raised the bar of quality in the discipline and been widely-adopted across the industry.

Position Description:

As a Principal Scientist in Medicinal Chemistry and Molecular Design at Pfizer you will play a key role in large, multi-disciplinary matrix teams from project inception through to delivery of clinical drug candidates. You may lead such teams, or sub-teams within the broader matrix team structure. You will also contribute to teams of scientists looking to combine Pfizer’s expertise and large-scale research investments, with external academic and biotech collaborations, to revolutionize our approach to the discovery and development of small molecule and synthetically-derived drugs.

  • Application of contemporary data analysis and design tools to drive effective target design and prioritization within a project
  • Effective use of both internal & external design resources available to the project team
  • Devise effective hit ID strategies to move projects through the Hit-to-Lead phase with scientific excellence, efficiency and speed
  • Play a key role in progressing projects through the Lead Optimization phase in partnership with enabling functions within Medicine Design to ensure the delivery of small molecule/synthetic drug candidates with scientific excellence, efficiency and speed
  • Contribute to the identification of new small molecule projects to the portfolio through collaborations with disease area biologists
  • Play a role in enhancing the external reputation of Pfizer’s Medicinal Chemistry, Molecular Design and synthetic Drug Discovery capabilities through publications and presentations at leading conferences
  • Work with local leadership to put in place an active program of self-development in medicinal chemistry and molecular design skills

  • Doctorate level degree in relevant area of science, or equivalent industrial experience
  • Minimum 3 years of relevant experience in the Pharmaceutical Industry with examples of strong learning agility and problem solving
  • Contemporary knowledge of the key Medicinal Chemistry concepts and design tools required for pharmaceutical drug discovery
  • Examples of peer-reviewed publications from scientific work to date

  • Examples of delivering impactful contributions to Med Chem projects
  • Examples of publications in Medicinal Chemistry/ Drug Discovery
  • Experience of working in matrixed teams of scientists to deliver project objectives

Along with a Resume/CV, please include a short research summary of your relevant research.
  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus

Interested candidates please apply at: